You can run a high salinity ...

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You can run a high salinity (salt water), brackish water or fresh water AS biological treatment.  You run into problems with float and cell losing when you swing salinity.  The name of the game is consistent when evaluating the biological environment.  Not having a handle on these swings with enough EQ capacity.  Surge as needed on these tanks to maintain hydraulic loading, organic loading and yes, in your case, salinity.  If you can do this, then you should be fine.

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If your salinity is relatively stable it’s possible to select an adapted biomass.

The problem can be in biological sludge sedimentation because salinity reduces the settling velocity and the halophylic bacteria doesn’t form good flocks. To use flotation instead sedimentation can solve this problem.

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